Author

Leihong Wu

National Center for Toxicological ResearchORCID 0000-0002-4093-3708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

James C. WilleyiD· 2 shared Rebecca L. KuskoiD· 2 shared Thomas M. BlomquistiD· 2 shared Tim R. MerceriD· 2 shared Wendell D. JonesiD· 2 shared Ali Moshrefi· 1 shared Aminah Wali· 1 shared Ana Granat· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersGenomics

James C. WilleyORCID

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2 papers

Recent·Most cited

Achieving reproducibility and accuracy in cancer mutation detection with whole-genome and whole-exome sequencing

Wenming Xiao, Luyao Ren, Zhong Chen, Li Tai Fang, Yongmei Zhao, Justin Lack, Meijian Guan, Bin Zhu, Erich B. Jaeger, Liz Kerrigan, Thomas M. Blomquist, Tiffany Hung, Marc Sultan, Kenneth B. Idler, Charles Lu, , Leming M. Shi

This study evaluates reproducibility and accuracy of cancer mutation detection using whole-genome and whole-exome sequencing across multiple sequencing centers and bioinformatics pipelines.

Nature Biotechnology · Sep 1, 2021Peer-reviewedGenomics

Advancing quality-control for NGS measurement of actionable mutations in circulating tumor DNA

James C. Willey, Tom Morrison, Brad Austermiller, Erin L. Crawford, Daniel J. Craig, Thomas M. Blomquist, Wendell D. Jones, Aminah Wali, Jennifer S. Lococo, Nathan Haseley, Todd A. Richmond, Natalia Novoradovskaya, Rebecca L. Kusko, Guangchun Chen, Quan-Zhen Li, , Joshua Xu

This paper develops a targeted NGS method with synthetic internal standards to improve detection of actionable mutations in ctDNA, increasing sensitivity and enabling quality control metrics.

bioRxiv · Apr 6, 2021 · PreprintGenomics