Yue Wang

This study identifies AUD-associated and ethanol-responsive proteins in human cortical organoids and finds candidate biomarkers linked to AUD and ethanol exposure.

The paper uses multiomic profiling of the caudate nucleus to identify gene expression and chromatin changes in AUD, linking them to risk genes through QTL analysis.

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

The paper identifies functional 3'-UTR variants linked to alcohol use disorder and related traits using MPRA and GWAS integration.

AIscEA integrates single-cell gene expression and chromatin accessibility data by aligning cell types based on biological consistency, showing improved robustness and accuracy over existing methods.

This study shows SARS-CoV-2 genes Nsp6, Nsp8, and M reduce ATP levels in hPSC-CMs, causing apoptosis and dysfunction, and identifies drugs that may counteract these effects.

WEVar integrates functional scores from multiple methods to predict noncoding regulatory variants, outperforming existing approaches in simulation and empirical studies.

The paper identifies functional variants in human brains with alcohol use disorders by combining allele-specific expression analysis with high-throughput reporter assays.