Kei Fukuda

Chromatin landscape of budding yeast acquiring H3K9 methylation and its reader molecule HP1

This study introduces H3K9 methylation and HP1 into budding yeast to examine their role in heterochromatin formation, finding they do not significantly alter chromatin structure or transcription.

H3K27 and H3K9 Methylation Mask Potential CTCF Binding Sites to Maintain 3D Genome Integrity

The paper investigates how H3K9 and H3K27 methylation regulate CTCF binding and 3D genome structure in mouse cells, showing that their loss disrupts chromatin organization and gene expression.

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin

This study shows that Resf1 is essential for placental development and trophoblast cell-specific heterochromatin configuration in mice, with loss of Resf1 leading to retroelement upregulation and developmental defects.

H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation

The paper investigates how H3K27me3 and the PRC1-H2AK119ub pathway work together to maintain heterochromatin structure after H3K9 methylation loss in mammalian cells.

Trichostatin A Treatment Has Little Impact on Nuclear compartments in Cells Depleted of H3K9me, H3K27me3, and uH2A

The paper investigates the effect of Trichostatin A on nuclear compartments in cells lacking H3K9me, H3K27me3, and uH2A, finding minimal impact on compartment structure despite increased H3K27ac levels.

AGO2 slicing restrains RTL1 to prevent vascular defects and lethal neonatal muscle failure

Transcriptional states of retroelement-inserted regions and KRAB zinc finger protein association regulate DNA methylation of retroelements in human male germ cells

The paper investigates how transcriptional states and KRAB-ZFPs regulate DNA methylation of retroelements in human male germ cells, revealing inter-individual epigenetic variation in sperm.

Functional correlation of H3K9me2 and nuclear compartment formation

The paper investigates the role of H3K9me2 in 3D genome organization by analyzing its distribution, transcriptome, and chromatin structure in mouse embryonic stem cells with altered H3K9 methyltransferase activity.