Author

Keijo T Mäkelä

University of TurkuORCID 0000-0002-4115-1767Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:rat· 1 Organism:zebrafish· 1

Frequent Co-Authors

Ari Alho· 2 shared Katja Hrovat· 2 shared Leire Bergara-MuguruzaiD· 2 shared Maarit LaineiD· 2 shared Miho NakamuraiD· 2 shared Akihisa OtakaiD· 1 shared Eriika SavontausiD· 1 shared Ilkka PaateroiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPharmacology & Toxicology

Ari Alho

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Suppressing Bone Resorption and Promoting Mineralization with Tetracycline Derivatives

Saeka Shimochi, Katja Hrovat, Uruj Sarwer, Leire Bergara-Muguruza, Ari Alho, Maarit Laine, Akihisa Otaka, Yasuhiko Iwasaki, Ilkka Paatero, Ulvi Kahraman Gürsoy, Keijo T Mäkelä, Eriika Savontaus, Jukka I. Salonen, Miho Nakamura

This study evaluates the effects of tetracycline derivatives on bone cells, finding dose-dependent dual effects on osteoclasts and osteoblasts, suggesting potential as dual-function therapies for osteoporosis.

bioRxiv · Feb 25, 2026 · PreprintPharmacology & Toxicology

Electrical Surface Polarization as a Functionalization Strategy to Improve Bone Regeneration of Apatite-Based Graft Materials

Katja Hrovat, Leire Bergara-Muguruza, Rumi Hiratai, Ari Alho, Maarit Laine, Keijo T Mäkelä, Kimihiro Yamashita, Miho Nakamura

This study shows electrical surface polarization improves bone regeneration of apatite-based grafts by enhancing osteoclast activity and implant-bone integration in vivo.

bioRxiv · Feb 18, 2026 · PreprintBioengineering