Ilkka Paatero

This study identifies SUMOylation as a therapeutic target in high-risk neuroblastoma, showing that SUMO pathway inhibitors like TAK-981 reduce tumor growth and are effective in combination with other therapies.

This study shows SHANK3 regulates endothelial cell motility and tissue mechanics, affecting vascular development in zebrafish and mice.

This study evaluates the effects of tetracycline derivatives on bone cells, finding dose-dependent dual effects on osteoclasts and osteoblasts, suggesting potential as dual-function therapies for osteoporosis.

This study identifies mitophagy's role in enhancing keratinocyte migration during wound healing via ANGPTL4 and metabolic reprogramming.

This study evaluates the pharmacokinetics and efficacy of tank-water administered dabrafenib in zebrafish with BRAF-mutant melanoma, showing rapid absorption, short half-life, and effective treatment with minimal toxicity.

This study uses phosphoproteomic analysis in zebrafish to show that ErbB inhibitors affect multiple signaling pathways, leading to similar physiological phenotypes.

This study uses high-resolution live imaging to observe tardigrade cellular changes during anoxia, revealing morphological and compositional shifts in storage cells.

This study shows that zebrafish embryos are sensitive to heat stress and that certain compounds enhance their neurological and cardiac toxicity under heat stress.

The paper identifies JNK1 downstream signalling hubs that regulate anxiety-like behaviours in zebrafish larvae using a behavioural assay and phosphoproteome analysis.

The paper examines the effects of caldesmon mutations in zebrafish embryos, finding mild developmental impacts and normal gross development, suggesting caldesmon may be a viable cancer therapy target.

DORM is a database of recurrent mutations in cancers, enabling search by protein, amino acid substitution, and regular expressions.

This study shows that aged zebrafish and turquoise killifish exhibit reduced fin regeneration and angiogenesis, with VEGF-A expression and vascular density changes, suggesting a key role for angiogenesis in aging wound healing.

This study investigates the role of Rasip1 in endothelial cell behaviors during angiogenesis and anastomosis in zebrafish, revealing its critical function in cell pairing and junction stability.

The paper identifies junction-based lamellipodia (JBL) as structures driving endothelial cell movement during vascular remodeling, showing their dependence on F-actin and VE-cadherin.