Unmixing of Imaging Mass Spectrometry Measurements Using Microscopy-Informed Constraints
Roger Moens, Nathan Heath Patterson, Lukasz G. Migas, Allison B. Esselman, Felipe A. Moser, Jeffrey M. Spraggins, Raf Van de Plas
This paper introduces TULIP, a method to unmix IMS data using microscopy constraints, improving analysis of tissue structures in synthetic and kidney datasets.
bioRxiv · Oct 29, 2025 · PreprintBioinformatics