Author

Mark P. deCaestecker

Vanderbilt UniversityORCID 0000-0001-7926-1673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:imaging· 3 Assay:spatial transcriptomics· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Jeffrey M. SpragginsiD· 3 shared Raf Van de PlasiD· 3 shared Allison B. EsselmaniD· 2 shared Angela R.S. KruseiD· 2 shared Ellie L. PingryiD· 2 shared Felipe A. MoseriD· 2 shared Haichun YangiD· 2 shared Jamie L. AlleniD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMolecular Biology

Jeffrey M. SpragginsORCID

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Author profile →

4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintApr 7, 2025

A Multimodal Imaging Pipeline for the Discovery of Molecular Markers of Cellular Neighborhoods

Thai H. Pham, Melissa A. Farrow, Lukasz G. Migas…·Jeffrey M. Spraggins

The paper develops a multimodal imaging pipeline to identify molecular markers of cellular neighborhoods in human kidney tissue by integrating imaging mass spectrometry and immunofluorescence data.

4 citations

humanspatial transcriptomics

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PathologyJCI InsightPeer-reviewedJan 23, 2025

Partial repair causes permanent defects in papillary structure and function after reversal of urinary obstruction

Thitinee Vanichapol, Alex Gonzalez, Rachel Delgado…·Mark P. deCaestecker

The paper shows that partial repair after urinary obstruction reversal causes permanent structural and functional defects in the renal papilla in mice.

2 citations

mouseexperimental assay

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BiochemistryKidney InternationalPeer-reviewedNov 19, 2024

Revealing In Situ Molecular Profiles of Glomerular Cell Types and Substructures with Integrated Imaging Mass Spectrometry and Multiplexed Immunofluorescence Microscopy

Allison B. Esselman, Felipe A. Moser, Léonore E. M. Tideman…·Jeffrey M. Spraggins

This paper integrates MALDI IMS and MxIF microscopy to analyze lipid and molecular profiles of glomerular cell types and substructures in human kidney tissue.

24 citations

humanspatial transcriptomics

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BioinformaticsbioRxivPreprintJul 16, 2021

Automated Segmentation of Kidney Nephron Structures by Deep Learning Models on Label-free Autofluorescence Microscopy for Spatial Multi-omics Data Acquisition and Mining

Nathan Heath Patterson, Ellie L. Pingry, Felipe A. Moser…·Jeffrey M. Spraggins

14 citations

humanspatial transcriptomics

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