Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters
Zixian Guo, Amrit Bagchi, Monika Dhankhar, Mohammad Dehghany, Vivek B. Shenoy
The paper identifies a membrane-feedback mechanism that converts single-channel mechanosensing into self-organized Piezo1 clusters through density and tension-dependent interactions.
bioRxiv · Sep 20, 2026 · PreprintBiophysics