Zixian Guo

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

The paper identifies a membrane-feedback mechanism that converts single-channel mechanosensing into self-organized Piezo1 clusters through density and tension-dependent interactions.

The paper introduces IntravChip, a microfluidic platform to study tumor cell intravasation and collect intravasated cells, showing it can quantify intravasation rates and test anti-metastatic drugs.

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

O-SNAP extracts and classifies chromatin features from SMLM data, detecting subtle changes in chromatin organization across biological transitions.