Author

Monika Dhankhar

University of PennsylvaniaORCID 0000-0002-5099-8863Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

Vivek B. ShenoyiD· 3 shared Zixian GuoiD· 3 shared Aayush KantiD· 2 shared Rohit JoshiiD· 2 shared Vinayak VinayakiD· 2 shared Abhijit MajumderiD· 1 shared Amrit BagchiiD· 1 shared Diana Isabel Cruz· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiophysics

Vivek B. ShenoyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Osmotic Coupling of Mechanics and Epigenetics Regulates Chromatin Phase Organization

Aayush Kant, Monika Dhankhar, Rohit Joshi, Zixian Guo, Vinayak Vinayak, Diana Isabel Cruz, Kedi Wang, Ivan Vladimirovich Surovtsev, Megan King, Abhijit Majumder, Jung-Hwan Lee, Hae-Won Kim, Elizabeth Hinde, Guilherme P. F. Nader, Vivek B. Shenoy

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

bioRxiv · Oct 30, 2026 · PreprintBiophysics

Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters

Zixian Guo, Amrit Bagchi, Monika Dhankhar, Mohammad Dehghany, Vivek B. Shenoy

The paper identifies a membrane-feedback mechanism that converts single-channel mechanosensing into self-organized Piezo1 clusters through density and tension-dependent interactions.

bioRxiv · Sep 20, 2026 · PreprintBiophysics

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

Monika Dhankhar, Zixian Guo, Aayush Kant, Ramin Basir, Rohit Joshi, Vinayak Vinayak, Su Chin Heo, Robert L. Mauck, Melike Lakadamyali, Vivek B. Shenoy

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

Nature Communications · Aug 25, 2025Peer-reviewedBiophysics