Francesc Posas

Basal association of a transcription factor favors early gene expression

The paper investigates how Ste12 binding site configurations and nucleosome positioning affect gene expression timing and level in yeast mating.

Perturbation-driven transcriptional heterogeneity impacts cell fitness

The paper maps cellular states in yeast using a single-cell transcriptome atlas generated from genetic perturbations and identifies regulators of transcriptional heterogeneity.

Somatic chromosome pairing has a determinant impact on 3D 1 chromatin organization

The paper investigates how chromosome pairing affects 3D chromatin organization in Drosophila, showing it reinforces intrachromosomal interactions but not compartmental organization.

Timing of gene expression in a cell-fate decision system

The paper quantifies gene expression kinetics in yeast mating pathway using single-cell measurements and identifies factors influencing transcription timing.