Camille Stephan‐Otto Attolini

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

This study shows that targeted KRAS(G12V) degradation causes durable lung adenocarcinoma regression in mice, with tumor relapse linked to proteolysis machinery dysregulation.

This study identifies a BMAL1-YAP transcriptional complex that hijacks enhancers in aged epidermis to promote inflammation by rewiring chromatin dynamics and co-regulating inflammation-related genes with NF-KB.

The paper maps cellular states in yeast using a single-cell transcriptome atlas generated from genetic perturbations and identifies regulators of transcriptional heterogeneity.

The paper identifies molecular signatures of Alzheimer's disease in AD mouse models and finds drugs that reverse these signatures and cognitive impairment.

The paper compares rotation-based scores for gene set analysis and finds the average of absolute values is the most powerful score.

This study shows TLK1/2 activity protects replication forks, contributes to chromatin silencing, and suppresses innate immune responses, with implications for immune evasion in chromosomally unstable cancers.

chroGPS2 provides tools for integrating, visualizing, and differentially analyzing epigenome maps across conditions and biological backgrounds.

The paper addresses technical biases in gene signature risk assessment in cancer cohorts by proposing a method to correct for systematic variability, ensuring accurate survival associations.

This study identifies Blimp-1's role in coordinating gene expression for tracheal lumen maturation in Drosophila by regulating chitin deposition and F-actin organization.