Author

Inga M. Spannaus

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron G. SchmidtiD· 1 shared Achilleas S FrangakisiD· 1 shared Attilio Vittorio VargiuiD· 1 shared Benjamin L. AllsupiD· 1 shared Bryan D. BrysoniD· 1 shared Charles Lee EvavoldiD· 1 shared Christopher GarrisiD· 1 shared Clara BörnseniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Aaron G. SchmidtORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cholesterol constrains pore formation by mammalian gasdermins

Yisha Liang, Isabella Rose Fraschilla, Sepideh Parvanian, Makiko Hayashi, Emerson Glassey, Gema González-Rubio, Inga M. Spannaus, Victoria Andrade, Benjamin L. Allsup, Fan Fei, Bryan D. Bryson, Aaron G. Schmidt, Tyler Jacks, Christopher Garris, Charles Lee Evavold

This study identifies Rabgef1 as a regulator of gasdermin pore formation by controlling membrane cholesterol, showing cholesterol depletion restores pyroptosis in cancer cells and tumors.

bioRxiv · Oct 15, 2026 · PreprintImmunology

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity

Mariya Lazarova, Thomas Eicher, Clara Börnsen, Hui Zeng, Mohd Athar, Ui Okada, Eiki Yamashita, Inga M. Spannaus, Max Borgosch, Hi-jea Cha, Attilio Vittorio Vargiu, Satoshi Murakami, Kay Diederichs, Achilleas S Frangakis, Klaas Martinus Pos

This study shows that a single conserved residue transfer between RND efflux pump clusters alters drug resistance and conformational dynamics.

Nature Communications · Nov 26, 2025Peer-reviewedBiochemistry