Musalula Sinkala

Mapping Epigenetic Gene Variant Dynamics: Comparative Analysis of Frequency, Functional Impact and Trait Associations in African and European Populations

The paper analyzes epigenetic gene variants in African and European populations to find frequency differences, trait associations, and functional impacts.

Unveiling the role of Tdark genes in genetic diseases and phenotypes through bioinformatics-based functional enrichment and network analyses

The paper investigates dark genes' role in genetic diseases and phenotypes using network and functional enrichment analyses across molecular datasets, identifying potential regulators and hub proteins associated with multiple diseases.

Shedding Light on the Dark Genome: Insights into the Genetic, CRISPR-based, and Pharmacological Dependencies of Human Cancers and Disease Aggressiveness

This study examines genetic, CRISPR-based, and pharmacological dependencies in human cancers by analyzing the dark genome, finding similar dependencies across light and dark genomes and linking dark gene mutations to worse patient outcomes.

Racial Disparities in the Genetic Landscape of Acute Myeloid Leukaemia from The Cancer Genome Atlas: Insights from a Bioinformatics Analysis

This study analyzes transcriptomic data from The Cancer Genome Atlas to identify genetic differences in AML between African and European patients, finding distinct pathway and kinase enrichments.

Mutational Landscape of Cancer-Driver Genes Across Human Cancers

The paper analyzes genome sequences of 20,066 tumors to identify driver mutations in cancer genes and links mutation patterns to survival outcomes.

A Machine Learning and Bioinformatic Analysis Reveals an Associated between Cell Surface Receptor Transcript Levels with Drug Response of Breast Cancer Cells and the Drug Off-Target Effects

The paper links drug response in breast cancer cells to cell surface receptor (CSR) transcript levels and reveals off-target effects through analysis of transcriptional landscapes and clinical data.

Multitrait Genome-Wide Analysis in the UK Biobank Reveals Novel and Distinct Variants Influencing Cardiovascular Traits in Africans and Europeans

This study identifies novel genetic variants associated with cardiovascular traits in African and European populations using the UK Biobank, highlighting population-specific genetic architecture.

Genome-wide Association Study of Pulmonary Function in Europeans and Africans from the UK Biobank Identifies Distinct Variants

This study identifies 817 genetic variants in Europeans and 3 in Africans associated with pulmonary function traits, highlighting distinct genetic architecture between populations.

Cell-to-cell and type-to-type heterogeneity of signaling networks: Insights from the crowd

The paper organizes a DREAM challenge to benchmark predictive models of single-cell signaling using mass cytometry data from breast cancer cell lines.

Proteogenomic Analysis of Pancreatic Cancer Subtypes

This study identifies two distinct pancreatic cancer subtypes through proteogenomic analysis and links them to altered molecular pathways and clinical outcomes.

ELF4 Expression is Associated with Worse Disease Outcomes and Increased Resistance to Anticancer Agents in Human Cancers

The paper investigates ELF4 expression in human cancers, finding it correlates with worse outcomes and drug resistance across 32 cancer types.

Integrated Molecular Characterisation of the MAPK Pathways in Human Cancers

The paper identifies cancer-associated mutations in MAPK pathway genes across 40,848 tumors and links them to poor outcomes and drug responses.

A Systems Approach Identifies Key Regulators of HPV-Positive Cervical Cancer

This study identifies key regulatory pathways and proteins in HPV-positive cervical cancer through systems-level analysis, suggesting potential drug targets.