Author

Joshua T. Lange

Stanford MedicineORCID 0000-0002-4246-6058Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Jens LuebeckiD· 2 shared Aditi Soni· 1 shared Andrey A. BobkoviD· 1 shared Anindya BagchiiD· 1 shared Aniruddha Deshpande· 1 shared Ashutosh Tiwari· 1 shared Badrinath R. KonetyiD· 1 shared Brian P. JamesiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Jens LuebeckORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 17, 2025

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

Ashutosh Tiwari, Utkarsha Paithane, Jordan Friedlein…·Anindya Bagchi

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

1 citation

humanDNA methylation

BioinformaticsbioRxivPreprintJan 22, 2020

AmpliconReconstructor: Integrated analysis of NGS and optical mapping resolves the complex structures of focal amplifications in cancer

Jens Luebeck, Ceyda Çoruh, Siavash R. Dehkordi…·Vineet Bafna

AmpliconReconstructor integrates optical mapping and NGS to resolve focal amplifications in cancer, revealing complex structures and origins of ecDNA and other rearrangements.

2 citations

humanwhole-genome sequencing