Luciana Lazar‐Stefanita

The paper identifies proto-point centromeres in Saccharomycodales yeast, showing they evolved from retrotransposon LTRs, supporting the hypothesis that point centromeres originated from ancestral retrotransposons.

This study replaces human variant histones in yeast, showing macroH2A1 disrupts chromatin organization and causes genome instability.

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

The paper uses CRISPR D-BUGS and chromosome swapping to identify and resolve genetic interactions in synthetic chromosomes, revealing unexpected links between transcription, inositol metabolism, and tRNA abundance.

This study examines how humanized nucleosomes in yeast affect chromatin structure, replication, and rDNA stability, revealing species-specific impacts on nuclear organization and function.

The paper shows that missense mutations in kinetochore proteins reduce chromosome instability in histone-humanized yeast by weakening microtubule attachments, promoting euploidy.

This study shows that twin rDNA loci in brewer's yeast form a single nucleolus and reveals position-dependent size changes in rDNA loci.

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.

The paper identifies Eco1's role in negatively regulating cohesin translocase activity during yeast mitosis, affecting DNA loop extrusion and chromosome folding.

The paper redesigns a genomic region for improved Hi-C analysis, revealing insights into homolog pairing and loop formation during meiosis.

The paper uses Hi-C to analyze chromosome structure dynamics in budding yeast during the cell cycle, revealing SMC-dependent structural transitions and mitotic reorganization.