Stefan Peidli

This study identifies Cph as a key regulator of intestinal stem cell proliferation and differentiation, showing its role in maintaining ISC and EE populations and remodeling progenitor transcriptomes.

Pertpy provides a modular framework for analyzing large-scale perturbation single-cell experiments, offering tools for metadata annotation and perturbation distance calculations.

The paper develops CCISM to distinguish cancer cells from normal epithelial cells in single-cell data, identifying a novel stem-like cell state in the colorectal cancer microenvironment.

The paper harmonizes single-cell perturbation datasets and introduces E-statistics for analyzing perturbation effects across diverse data sources.

The paper evaluates distance metrics for single-cell RNA-seq data and recommends mean squared error for comparing populations and evaluating gene expression models.

The paper evaluates dexamethasone and anti-SARS-CoV-2 antibodies in hamster models, showing reduced viral burden with antibodies and anti-inflammatory effects with dexamethasone, with synergistic benefits when combined.

scVelo fits a likelihood-based model of full splicing kinetics, extending RNA velocity to transient cell states and adding gene-specific kinetic rates, a latent time and putative driver genes.