Author

Zilong Wen

Chinese University of Hong KongORCID 0000-0002-4260-7682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:zebrafish· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Shizheng ZhaoiD· 2 shared Thi Huong TrinhiD· 2 shared Chuan GaoiD· 1 shared Haidi YiniD· 1 shared Hao Zhu· 1 shared Haoyue KuangiD· 1 shared Huating WangiD· 1 shared Jin XuiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersDevelopmental Biology

Shizheng ZhaoORCID

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3 papers

Recent·Most cited

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

Yi Wu, Weilin Guo, Haoyue Kuang, Xiaohai Wu, Thi Huong Trinh, Yuexin Wang, Shizheng Zhao, Zilong Wen, Tao Yu

This study shows that PU.1 dosage regulates microglia maintenance in zebrafish and mammals through cell competition and apoptosis.

eLife · Jul 17, 2025Peer-reviewedDevelopmental Biology

Bona fide hematopoietic stem cells in zebrafish originate from the supra-intestinal artery

Shachuan Feng, Rui Qu, Yingzhu He, Tingting Huang, Youqi Wang, Thi Huong Trinh, Kefan Cheng, Shizheng Zhao, Ying Kao Huang, Hao Zhu, Sicong He, Zilong Wen

This study shows that in zebrafish, hematopoietic stem cells (HSCs) originate from the supra-intestinal artery, not the dorsal aorta, as previously thought.

bioRxiv · May 20, 2025 · PreprintDevelopmental Biology

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

Xianwei Chen, Yanfeng Li, Jin Xu, Yong Cui, Qian Wu, Haidi Yin, Yuying Li, Chuan Gao, Liwen Jiang, Huating Wang, Zilong Wen, Zhong‐Ping Yao, Zhenguo Wu

This study identifies Styxl2 as a regulator of de novo sarcomere assembly by promoting degradation of non-muscle myosin IIs through autophagy.

eLife · May 5, 2023Peer-reviewedDevelopmental Biology