Huating Wang

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

This study systematically profiles CRISPR/Cas9 repair outcomes in skeletal muscle stem cells, revealing both expected and novel large on-target modifications and their regulation by repair pathways.

caRBP-Pred predicts chromatin-associated RNA-binding proteins using short peptide sequences, achieving an AUC of 0.81 and identifying 52 potential caRBPs in mice.

This study uses spatial transcriptomics to analyze MDA5+ dermatomyositis muscles, revealing distinct transcriptomic profiles, immune cell infiltration, and vascular inflammation.

This study maps G-quadruplexes in skeletal muscle stem cells and shows their role in promoting activation and regeneration through chromatin looping and transcription factor binding.

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

The paper investigates how three-dimensional chromatin domain structures influence gene regulation and finds that domain surfaces are enriched for regulatory elements and disease variants.

This study identifies RNA binding proteins (RBPs) as key regulators of TAD organization through their enrichment at TAD boundaries and synergistic interaction with nascent transcripts.

This study shows DHX36 binding remodels RNA structure, particularly in 3UTRs, leading to decreased mRNA abundance via m6A and YTHDF1 interactions.

This study identifies Styxl2 as a regulator of de novo sarcomere assembly by promoting degradation of non-muscle myosin IIs through autophagy.

This study identifies YTHDC1 as a critical regulator of muscle stem cell activation and proliferation by modulating mRNA splicing and nuclear export during regeneration.

This study identifies PAM-1, a long non-coding RNA that regulates skeletal muscle satellite cell activation and aging by trans-regulating Timp2 expression with Ddx5.

This study develops a CRISPR/Cas9/AAV9-sgRNA system for in vivo genome editing in muscle satellite cells to investigate key transcription factors during activation and regeneration.