HIF-1α and RhoA Drive Enhanced Motility and Aerotaxis of Polyaneuploid Prostate Cancer Cells in Hypoxia
Noreen Hosny, Shengkai Li, Sarah R. Amend, Robert A. Gatenby, Kenneth J. Pienta, Joel S. Brown, Junle Qu, Robert H. Austin
The paper shows polyaneuploid prostate cancer cells under hypoxia exhibit enhanced motility and aerotaxis driven by HIF-1α and RhoA, enabling invasion and intravasation.
bioRxiv · Sep 3, 2025 · PreprintCancer Biology