Author

Noreen Hosny

Princeton UniversityORCID 0009-0001-1804-252XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Brent R. StockwelliD· 1 shared Elham AziziiD· 1 shared Jia Yi Zhang· 1 shared Joel S. BrowniD· 1 shared John Shaw Moazami· 1 shared Joshua D. MyersiD· 1 shared Junle QuiD· 1 shared Kaylee W Fang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Brent R. StockwellORCID

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2 papers

Recent·Most cited

LYNX: a deep generative model for linking spatial dynamics and cellinteractions in multimodal spatial data

Yinuo Jin, Joshua D. Myers, Presha Rajbhandari, Jia Yi Zhang, Kaylee W Fang, John Shaw Moazami, Noreen Hosny, Brent R. Stockwell, Elham Azizi

LYNX is a deep generative model that integrates multimodal spatial data to model spatial dynamics and cell-cell interactions across tissues.

bioRxiv · Jul 10, 2026 · PreprintBioengineering

HIF-1α and RhoA Drive Enhanced Motility and Aerotaxis of Polyaneuploid Prostate Cancer Cells in Hypoxia

Noreen Hosny, Shengkai Li, Sarah R. Amend, Robert A. Gatenby, Kenneth J. Pienta, Joel S. Brown, Junle Qu, Robert H. Austin

The paper shows polyaneuploid prostate cancer cells under hypoxia exhibit enhanced motility and aerotaxis driven by HIF-1α and RhoA, enabling invasion and intravasation.

bioRxiv · Sep 3, 2025 · PreprintCancer Biology