Author

Jonathan Welch

Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID 0000-0002-4285-5256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Taku TsukidateiD· 2 shared Xuanwen LiiD· 2 shared Alyssa Q. StivingiD· 1 shared Anita P. LiuiD· 1 shared Ansuman SahooiD· 1 shared Geetanjali PendyalaiD· 1 shared Rong‐Sheng YangiD· 1 shared Shannon RiveraiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

Taku TsukidateORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of Chemical Tools for Polysorbate-Degradative Enzyme Control in Biopharmaceutical Upstream Process via Multi-Omic Profiling of Host Cell Clones

Taku Tsukidate, Ansuman Sahoo, Geetanjali Pendyala, Rong‐Sheng Yang, Jonathan Welch, Sri Ranganayaki Madabhushi, Xuanwen Li

The paper identifies PPARγ as a regulator of PSDEs in CHO cells and shows that its antagonists reduce PSDE levels and improve PS stability without affecting mAb production.

ACS Chemical Biology · Apr 18, 2025Peer-reviewedBioengineering

Systematic Optimization of Activity-Based Protein Profiling for Identification of Polysorbate-Degradative Enzymes in Biotherapeutic Drug Substance Down to 10 ppb

Taku Tsukidate, Anita P. Liu, Shannon Rivera, Alyssa Q. Stiving, Jonathan Welch, Xuanwen Li

This study optimizes an activity-based protein profiling workflow to detect polysorbate-degradative enzymes at 10 ppb in biotherapeutic samples.

Journal of the American Society for Mass Spectrometry · Nov 21, 2024Peer-reviewedBioengineering