Author

Sri Ranganayaki Madabhushi

Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID 0000-0003-3847-3084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Ansuman SahooiD· 3 shared Taku TsukidateiD· 3 shared Xuanwen LiiD· 3 shared Geetanjali PendyalaiD· 2 shared Rong‐Sheng YangiD· 2 shared Alyssa Q. StivingiD· 1 shared Jonathan WelchiD· 1 shared Shannon RiveraiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

Ansuman SahooORCID

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3 papers

Recent·Most cited

BioengineeringBiotechnology ProgressPeer-reviewedJun 20, 2026

Prolonged autophagy induction correlates with host cell protein reduction in CHO cell culture

Ansuman Sahoo, Taku Tsukidate, Geetanjali Pendyala…·Sri Ranganayaki Madabhushi

The paper investigates how autophagy induction reduces host cell proteins in CHO cell cultures, improving polysorbate stability and mAb productivity.

DOI 10.1002/btpr.88528

mouseproteomics

𝕏 PostBluesky

BioengineeringACS Chemical BiologyPeer-reviewedApr 18, 2025

Discovery of Chemical Tools for Polysorbate-Degradative Enzyme Control in Biopharmaceutical Upstream Process via Multi-Omic Profiling of Host Cell Clones

Taku Tsukidate, Ansuman Sahoo, Geetanjali Pendyala…·Xuanwen Li

The paper identifies PPARγ as a regulator of PSDEs in CHO cells and shows that its antagonists reduce PSDE levels and improve PS stability without affecting mAb production.

7 citations

mouseproteomics

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BioengineeringAnalytical ChemistryPeer-reviewedJul 26, 2024

diaPASEF Enables High-throughput Proteomic Analysis of Host Cell Proteins for Biopharmaceutical Process Development

Taku Tsukidate, Alyssa Q. Stiving, Shannon Rivera…·Xuanwen Li

The paper evaluates diaPASEF for HCP analysis in biopharmaceutical processes, showing improved quantification and throughput compared to standard methods.

13 citations

proteomicsdeep learning

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