Author

Nils-Alexander Lakomek

Forschungszentrum JulichORCID 0000-0002-4285-6339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Lothar GremeriD· 2 shared Wolfgang HoyeriD· 2 shared Antje WilluweitiD· 1 shared Celina M Schulz· 1 shared Dieter WillboldiD· 1 shared Gültekin TamgüneyiD· 1 shared Ian GeringiD· 1 shared Janine KutzscheiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Lothar GremerORCID

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2 papers

Recent·Most cited

Direct NMR evidence for transient binding of the vesicular SNARE protein synaptobrevin-2/VAMP2 to the α-synuclein C-terminus

Sophia Werner, Tobias Stief, Celina M Schulz, Katharina Vormann, Robin Backer, Marie P Schutzmann, Lothar Gremer, Wolfgang Hoyer, Nils-Alexander Lakomek

This study provides direct evidence of transient binding between α-synuclein C-terminus and synaptobrevin-2 using NMR and other biophysical methods, suggesting a role in neuronal exocytosis.

bioRxiv · Nov 4, 2026 · PreprintBiophysics

Direct disassembly of alpha-syn preformed fibrils into native alpha-syn monomers by an all-D-peptide

Marc M. Sevenich, Ian Gering, Madita Vollmer, Selma Aghabashlou Saisan, Markus Tusche, Tatsiana Kupreichyk, Thomas A. Pauly, Matthias Stoldt, Wolfgang Hoyer, Antje Willuweit, Janine Kutzsche, Nils‐Alexander Lakomek, Luitgard Nagel‐Steger, Lothar Gremer, Gültekin Tamgüney, , Dieter Willbold

This paper develops all-D-peptide ligands that disassemble alpha-syn preformed fibrils into monomers, showing potential for treating Parkinson's disease.

bioRxiv · Dec 11, 2023 · PreprintNeuroscience