Author

Marc M. Sevenich

Forschungszentrum JülichORCID 0000-0002-7036-6927Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Dieter WillboldiD· 2 shared Ian GeringiD· 2 shared Jeannine MohrlüderiD· 2 shared Antje WilluweitiD· 1 shared Gültekin TamgüneyiD· 1 shared Janine KutzscheiD· 1 shared Joop van den HeuveliD· 1 shared Lothar GremeriD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Dieter WillboldORCID

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2 papers

Recent·Most cited

Direct disassembly of alpha-syn preformed fibrils into native alpha-syn monomers by an all-D-peptide

Marc M. Sevenich, Ian Gering, Madita Vollmer, Selma Aghabashlou Saisan, Markus Tusche, Tatsiana Kupreichyk, Thomas A. Pauly, Matthias Stoldt, Wolfgang Hoyer, Antje Willuweit, Janine Kutzsche, Nils‐Alexander Lakomek, Luitgard Nagel‐Steger, Lothar Gremer, Gültekin Tamgüney, , Dieter Willbold

This paper develops all-D-peptide ligands that disassemble alpha-syn preformed fibrils into monomers, showing potential for treating Parkinson's disease.

bioRxiv · Dec 11, 2023 · PreprintNeuroscience

Conversion rate to the secondary conformation state in the binding mode of SARS-CoV-2 spike protein to human ACE2 may predict infectivity efficacy of the underlying virus mutant

Marc M. Sevenich, Joop van den Heuvel, Ian Gering, Jeannine Mohrlüder, Dieter Willbold

The paper demonstrates that SARS-CoV-2 spike protein binding to ACE2 involves a two-step process with a secondary rate transition that enhances complex stability, and this is also observed in the B.1.1.7 variant.

bioRxiv · Jul 14, 2021 · PreprintMolecular Biology