Direct disassembly of alpha-syn preformed fibrils into native alpha-syn monomers by an all-D-peptide
Marc M. Sevenich, Ian Gering, Madita Vollmer, Selma Aghabashlou Saisan, Markus Tusche, Tatsiana Kupreichyk, Thomas A. Pauly, Matthias Stoldt, Wolfgang Hoyer, Antje Willuweit, Janine Kutzsche, Nils‐Alexander Lakomek, Luitgard Nagel‐Steger, Lothar Gremer, Gültekin Tamgüney, , Dieter Willbold
This paper develops all-D-peptide ligands that disassemble alpha-syn preformed fibrils into monomers, showing potential for treating Parkinson's disease.
bioRxiv · Dec 11, 2023 · PreprintNeuroscience