Localised activity of reverse gyrase at gene regulatory elements
Paul Villain, Vladislav Kuzin, Augustin Darennes-Degaugue, Florence Lorieux, Antoine Hocher, Romain Le Bars, Tobias Warnecke, Laura Baranello, Tamara Basta
This study investigates reverse gyrase activity in Thermococcus kodakarensis, showing it stabilizes regulatory regions by acting on hyper-negatively supercoiled DNA.
bioRxiv · Dec 8, 2025 · PreprintMicrobiology