Author

Paul Villain

University of OxfordORCID 0009-0002-5120-1884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Antoine HocheriD· 2 shared Tobias WarneckeiD· 2 shared Alex MontoyaiD· 1 shared Augustin Darennes-DegaugueiD· 1 shared Chad Whilding· 1 shared Florence LorieuxiD· 1 shared Jacques SerizayiD· 1 shared Laura BaranelloiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

Antoine HocherORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 21, 2026

Chromatin is dispensable for bacterial life

Paul Villain, Antoine Hocher, Jacques Serizay…·Tobias Warnecke

This study deletes nine NAPs from E. coli to create a strain lacking native chromatin, revealing gene expression homogenization and demonstrating that bacterial life can proceed without chromatin proteins.

1 citation

E. coliDNA methylation

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MicrobiologybioRxivPreprintDec 8, 2025

Localised activity of reverse gyrase at gene regulatory elements

Paul Villain, Vladislav Kuzin, Augustin Darennes-Degaugue…·Tamara Basta

This study investigates reverse gyrase activity in Thermococcus kodakarensis, showing it stabilizes regulatory regions by acting on hyper-negatively supercoiled DNA.

1 citation

DNA methylationexperimental assay

𝕏 PostBluesky