Author

Vladislav Kuzin

Karolinska InstitutetORCID 0000-0002-7139-1884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Laura BaranelloiD· 3 shared Alessia LoffredaiD· 1 shared Andrej PaludaiD· 1 shared Antoine HocheriD· 1 shared Augustin Darennes-DegaugueiD· 1 shared Bea JagodiciD· 1 shared Brian Saidel Lopez DuraniD· 1 shared Carl MölleriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

Laura BaranelloORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedFeb 9, 2026

MYC modulates TOP2A diffusion to promote substrate detection and activity

Donald P. Cameron, Kathryn Jackson, Alessia Loffreda…·Laura Baranello

This study shows MYC enhances TOP2A diffusion, promoting its substrate binding and chromatin engagement, thereby stimulating topoisomerase activity.

2 citations

humanexperimental assay

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MicrobiologybioRxivPreprintDec 8, 2025

Localised activity of reverse gyrase at gene regulatory elements

Paul Villain, Vladislav Kuzin, Augustin Darennes-Degaugue…·Tamara Basta

This study investigates reverse gyrase activity in Thermococcus kodakarensis, showing it stabilizes regulatory regions by acting on hyper-negatively supercoiled DNA.

1 citation

DNA methylationexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedAug 12, 2025

Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability

Tae-Hee Lee, Colina X. Qiao, Vladislav Kuzin…·Philipp Oberdoerffer

The paper identifies macroH2A1 splicing as a regulator of TOP1 activity and shows its impact on cancer vulnerability to TOP1 inhibitors.

4 citations

humanDNA methylation

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