Antoine Hocher

This study deletes nine NAPs from E. coli to create a strain lacking native chromatin, revealing gene expression homogenization and demonstrating that bacterial life can proceed without chromatin proteins.

This study identifies and characterizes cinquedea, a bactericidal phospholipase from the archaeon Haloferax larsenii that kills halophilic bacteria by damaging their cell membranes.

The paper shows that the ParB-CTPase fold can be repurposed as an ATPase toxin in bacterial contact-dependent growth inhibition systems, with toxic effects in both plant and animal cells.

This study investigates reverse gyrase activity in Thermococcus kodakarensis, showing it stabilizes regulatory regions by acting on hyper-negatively supercoiled DNA.

The paper identifies the ParB-CTPase fold as a versatile NTP-binding module found across diverse organisms, showing expanded nucleotide specificity and functional diversity through domain fusions.

This study identifies antagonistic interactions between archaea and bacteria by analyzing genome sequences and demonstrating the antibacterial activity of archaeal peptidoglycan hydrolases.

This study shows that histones are essential and form chromatin in bacteria, with a unique DNA binding mode compared to archaea and eukaryotes.

This study expresses archaeal histones in E. coli to investigate chromatinization challenges, finding nucleosome occupancy correlates with transcriptional repression but minimal growth impact.

The paper shows that H3K79 methylation blocks Sir3 spreading in yeast, revealing discrete subtelomeric domains defined by chromatin transitions.