Daniel R. Brison

Interaction between gene expression and morphokinetic parameters in undisturbed human embryo culture

This study compares gene expression in human embryos cultured in time-lapse systems versus conventional incubators and identifies molecular mechanisms linking morphokinetic parameters to embryo development.

Effect of glucose concentration in culture medium on the human preimplantation embryo methylome

This study examines how varying glucose concentrations in culture medium affect the DNA methylome of human preimplantation embryos, finding significant changes in methylation and gene expression.

Deep learning pipeline reveals key moments in human embryonic development predictive of live birth in IVF

The paper uses deep learning to identify key developmental stages in human embryos that predict viability, improving IVF embryo selection.

Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantation

The paper models human embryo implantation using blastocysts and endometrial epithelial cells, showing EEC-induced syncytiotrophoblast differentiation as the mechanism for embryonic invasion.

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos

This paper applies extracellular flux analysis to measure mitochondrial function in mammalian oocytes and embryos, showing real-time OCR partitioning and stable efficiency during development.

Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm

The paper compares the interactome networks of human embryonic stem cell lines with their tissue of origin, finding limited transcriptome overlap but enriched network properties related to transcriptional activity.