Nicola Bates

Human pluripotent stem cell model of multiple epiphyseal dysplasia with MATN3 mutation identifies altered Matrix organisation and upregulation of the cholesterol biosynthesis pathway

This study uses hPSCs to model MED with MATN3 mutations, revealing altered matrix organisation and upregulated cholesterol biosynthesis pathway.

Genome editing of a low-penetrance albinism-associated variant in TYR in patient-derived pluripotent stem cells

The paper corrects a TYR variant associated with albinism in patient-derived iPSCs to create a model for studying pigmentation biology.

Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations

This study uses HNF1B mutant kidney organoids to reveal molecular and physiological defects in dysplastic kidney malformations and identify potential therapeutic targets.

Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis

This study shows that adding TTNPB and timed BMP2 to hPSC differentiation improves chondrogenesis, upregulating genes related to skeletal and cartilage development.

SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation

This study shows that SIRT1 activation increases ECM gene expression but reduces GAG retention during hESC chondrogenesis, suggesting a complex role in cartilage development.

Optogenetic control of the Bone Morphogenetic Protein signalling pathway through engineered blue light-sensitive receptors

This paper develops an optogenetic system to control BMP signaling using blue light, enabling precise and dynamic activation in human cells.

Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm

The paper compares the interactome networks of human embryonic stem cell lines with their tissue of origin, finding limited transcriptome overlap but enriched network properties related to transcriptional activity.