Adam Stevens

Higher-Order Organization Links Circulating Metabolites to Glucocorticoid Action in Human Adipose Tissue

The paper investigates how glucocorticoid exposure affects adipose metabolism and identifies a circulating biomarker, the phenylalanine/kynurenine ratio, that reflects GC state and has potential for personalized therapy.

Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons

This study examines epigenome and transcriptome changes in KS1 iPSCs and neuronal differentiation stages, identifying altered H3K4 methylation and gene expression patterns.

Spatial transcriptomic profiling reveals distinct signatures in acute versus chronic wounds through hypergraph modelling and transcriptomic entropy analysis.

This paper uses spatial transcriptomics and hypergraph analysis to identify distinct transcriptomic signatures in acute versus chronic wounds, revealing pathway differences and entropy patterns.

Single Cell Transcriptomic Modelling of the Fallopian Tube Epithelium Identifies Cellular Specialisation, Novel Differentiation Trajectories, and Gene Network Associations with Ectopic Pregnancy

The paper uses single-cell transcriptomic data to identify cellular specialization, differentiation trajectories, and gene network associations with ectopic pregnancy in fallopian tube epithelium.

Interaction between gene expression and morphokinetic parameters in undisturbed human embryo culture

This study compares gene expression in human embryos cultured in time-lapse systems versus conventional incubators and identifies molecular mechanisms linking morphokinetic parameters to embryo development.

Analysis of higher order interactions quantifies co-ordination in the epigenome and reveals novel biological relationships in Kabuki syndrome

The paper quantifies higher order interactions in DNA methylation data from Kabuki syndrome patients and controls, revealing reduced epigenome complexity and novel biological relationships.

Warming During Embryogenesis Induces a Lasting Transcriptomic Signature in Fishes

The paper shows that developmental warming alters transcriptomic network organisation in fishes, with lasting effects on gene interaction entropy and future temperature responsiveness.

Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio

This study shows that transient grb10a knockdown in zebrafish leads to permanent transcriptomic changes and persistent cardiometabolic phenotypes in adulthood.

Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantation

The paper models human embryo implantation using blastocysts and endometrial epithelial cells, showing EEC-induced syncytiotrophoblast differentiation as the mechanism for embryonic invasion.

Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm

The paper compares the interactome networks of human embryonic stem cell lines with their tissue of origin, finding limited transcriptome overlap but enriched network properties related to transcriptional activity.

Regional protein expression in human Alzheimer’s brain correlates with disease severity

This study identifies region-specific protein expression changes in human Alzheimer’s brains, revealing disease severity gradients and protective profiles in the cerebellum.