Cancer BiologyMolecular TherapyPeer-reviewed
Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.
Nannan Li, Jesse L. Rodriguez, Yibo Yin…·Donald M. O’Rourke
This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.
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