Joseph A. Fraietta

LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells

The paper uses long-read sequencing to analyze proviral variation in lentiviral vector-transduced CAR T cells, finding deletions and mutations affecting transgene function.

An integrated enzymatic and computational pipeline for quantifying off-target base-editing

The paper introduces a combined enzymatic and computational pipeline to identify off-target base-editing sites in human cells on a genome-wide scale.

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

Collagen modification remodels the sarcoma tumor microenvironment and promotes resistance to immune checkpoint inhibition

This study shows that Plod2 promotes immune evasion in UPS sarcomas and that its inhibition enhances anti-Pd1 therapy efficacy.