Donald M. O’Rourke

This paper identifies hydralazine as an inhibitor of cysteamine dioxygenase (ADO), showing its role in treating preeclampsia and inducing senescence in glioblastoma.

The paper shows that delivering CAR-T cells via a hydrogel in the resection cavity improves survival in mice with recurrent glioblastoma.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

The paper shows that patient-derived glioblastoma organoids can reflect CAR-T cell treatment responses in real-time, correlating with clinical outcomes in patients.

This study uses temporal multi-modal single-cell profiling to show CAR-T cells interact dynamically with glioblastoma cells, including antigen-negative ones, and reduce their proliferation through IFN-gamma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.