Yichen Li

The paper compares microbiota and metabolome profiles of quiescent Crohn's disease patients with their healthy first-degree relatives to identify biomarkers associated with disease relapse.

OSPALC provides a one-step PCR method for amplicon library construction, reducing cost and time compared to commercial kits, and includes a QIIME2 analysis pipeline.

The paper identifies eight keystone species in NAFLD gut microbiota using causal inference and dynamic intervention modeling, which can restore microbial composition toward a normal state.

This study shows that inhibiting PIKFYVE kinase rescues both gain- and loss-of-function C9ORF72 disease mechanisms in mouse models of ALS/FTD.