Berislav V. Zloković

Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins

The paper shows oral DFO reduces brain iron and iron-related proteins in mice, suggesting potential therapeutic benefits for early-stage Alzheimer's.

Neuronally differentiated endothelial cell subtype regulates organ blood flow and immune balance

The paper identifies and characterizes neuro-endothelial cells (NECs) in mouse brain and kidney, showing their role in regulating blood flow and immune balance through Nos1 and Cytl1.

Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes

The paper characterizes human iPSC-derived brain pericytes, showing they closely resemble primary pericytes in protein composition and function, and demonstrate therapeutic potential in neurological disorders.

Integrative mapping of spatial transcriptomic and amyloid pathology in Alzheimer's disease at single-cell resolution

This study uses Stereo-seq to analyze spatial transcriptomics in 5xFAD mice, linking neuronal transcriptomic changes to amyloid pathology at single-cell resolution.

Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo

This study shows that inhibiting PIKFYVE kinase rescues both gain- and loss-of-function C9ORF72 disease mechanisms in mouse models of ALS/FTD.