Richard J. Piercy

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

This study investigates dystrophin mRNA and protein expression dynamics during muscle repair, revealing post-transcriptional control mechanisms and suggesting degradation as a therapeutic target.

This paper introduces a novel DMD mouse model with non-uniform dystrophin expression and shows that partial dystrophin expression protects against muscle pathology.

The paper quantifies age-associated activity changes in DE50-MD dogs using accelerometers, finding reduced activity and increased rest time in affected dogs compared to controls.

This study tracks cardiac changes in DE50-MD dogs with DMD, showing worsening fibrosis and function decline over time, validated by CMR and histopathology.

This study describes the cardiac phenotype of DE50-MD dogs, a dystrophin-deficient model of DMD, showing early cardiac changes similar to human DMD patients.

The paper evaluates reference genes for qPCR normalization in a rat tendon injury model, identifying stable genes and highlighting unstable ones.

The paper develops a method using the HSB color space to rapidly quantify muscle fibrosis and lysosomal activity in histological images, validated across animal models.

The paper identifies suitable reference genes for normalizing qPCR data in developing mouse embryos using multiple algorithms and shows that AP3D1, RPL13A, and PAK1IP1 are consistently reliable.