Kevin C. Vavra

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis

This study aligns Duplex Sequencing with transgenic rodent mutation assay data to assess in vivo NDMA-induced mutagenesis, finding dose-dependent mutation frequency increases and concordant benchmark dose estimates.

Allelic imbalance reveals widespread germline-somatic regulatory differences and prioritizes risk loci in Renal Cell Carcinoma

The paper identifies allele-specific quantitative trait loci (asQTLs) in RCC, showing their enrichment in GWAS risk loci and linking them to hypoxia pathway interactions.

Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

This study identifies 21 novel candidate susceptibility genes for high grade serous ovarian cancer using transcriptome-wide association analysis across multiple tissue types.