Pharmacology & ToxicologyArchives of ToxicologyPeer-reviewed
Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis
Anne L. Ashford, Daniela Nachmanson, John W. Wills…·Anthony M. Lynch
This study aligns Duplex Sequencing with transgenic rodent mutation assay data to assess in vivo NDMA-induced mutagenesis, finding dose-dependent mutation frequency increases and concordant benchmark dose estimates.
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