Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
Chunxing Yang, Tao Qiao, Jia Hui Yu, Hongyan Wang, Yansu Guo, Johnny S. Salameh, Jake Metterville, Sepideh Parsi, Issa Olakunle Yusuf, Robert H. Brown, Huaibin Cai, Zuoshang Xu
This study shows that low-level overexpression of wild-type TDP-43 in mice causes late-onset, progressive neurodegeneration and paralysis, mimicking aspects of ALS and other TDP-43-related disorders.
PLoS ONE · Feb 3, 2022Peer-reviewedGenetics