Author

Laura Ruíz-Cañas

Instituto de Investigaciones Biomédicas Sols-MorrealeORCID 0000-0002-4373-2573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alexandra BerningeriD· 1 shared Bruno SáinziD· 1 shared C. Dai· 1 shared D. Bakırdöğen· 1 shared Deniz DemircioğluiD· 1 shared Dietrich Alexander RuessiD· 1 shared Ezgi Kaya-AksoyiD· 1 shared F. Schmidt· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexandra BerningerORCID

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1 paper

Recent·Most cited

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation

D. Bakırdöğen, Kıvanç Görgülü, J. Xin, L. Richter, Sonia Alcalá, Laura Ruíz-Cañas, C. Dai, Katrin J. Frank, Nan Wu, Kalliope Nina Diakopoulos, H. Ozturk, Deniz Demircioğlu, Katja Peschke, R. Ranjan, Francesca Fusco, , Hana Algül

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

Molecular Cancer · Dec 15, 2025Peer-reviewedCancer Biology