The paper conducts an X-chromosome association study in Latin American cohorts, identifying new loci linked to Parkinson Disease and replicating previous findings.

medRxiv · Jan 31, 2023 · PreprintGenetic & Genomic Medicine

Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort

Douglas P. Loesch, Andréa R. V. R. Horimoto, Elif Irem Sarihan, Miguel Inca‐Martinez, Emily Mason, Mario Cornejo‐Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison H. Sarapura‐Castro, Andrea Rivera‐Valdivia, Ángel C. Medina, Elena Diéguez, Víctor E. Raggio, Andres Lescano, , Timothy D. O’Connor

The paper constructs and validates a polygenic risk score for Parkinson's disease in a Latino cohort, finding ancestry-related biases and haplotype associations at the SNCA locus.

Parkinsonism & Related Disorders · Jun 18, 2022Peer-reviewedGenetic & Genomic Medicine

Characterizing the genetic architecture of Parkinson's disease in Latinos

Douglas P. Loesch, Andréa R. V. R. Horimoto, Karl Heilbron, Elif Irem Sarihan, Miguel Inca‐Martinez, Emily Mason, Mario Cornejo‐Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison H. Sarapura‐Castro, Andrea Rivera‐Valdivia, Ángel C. Medina, Elena Diéguez, Víctor E. Raggio, , Ignacio Fernandez Mata

This study conducts the first GWAS of Parkinson's disease in Latinos, identifies SNCA as significant, and finds genetic overlap with Europeans.

Annals of Neurology · Jul 6, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide Analysis of Copy Number Variation in Latin American Parkinson's Disease Patients

Elif Irem Sarihan, Eduardo Pérez‐Palma, Lisa‐Marie Niestroj, Douglas P. Loesch, Miguel Inca‐Martinez, Andréa R. V. R. Horimoto, Mario Cornejo‐Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison H. Sarapura‐Castro, Andrea Rivera‐Valdivia, Elena Diéguez, Víctor E. Raggio, Andres Lescano, , Ignacio Fernandez Mata

The paper analyzes copy number variants in Latin American Parkinson's disease patients and finds enrichment of variants overlapping known Parkinson's genes, particularly PARK2, associated with early-onset disease.

Movement Disorders · Nov 5, 2020Peer-reviewedGenetic & Genomic Medicine

Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM-1 and CD1

Luis Jaramillo‐Valverde, Kelly S. Levano, Isolina Villanueva, Meylin Hidalgo, Marco Cornejo, Pilar Mazzetti, Mario Cornejo‐Olivas, César Sánchez, Julio A. Poterico, Julio Valdivia‐Silva, Heinner Guio

The paper investigates the association between genetic polymorphisms in IL-17, ICAM-1, and CD1 genes and susceptibility to Guillain-Barré Syndrome (GBS) in a mestizo population during a 2018 outbreak.

Molecular Genetics & Genomic Medicine · Aug 28, 2019Peer-reviewedMolecular Biology