Heinner Guio

This paper shows that trustworthy agentic genome interpretation requires executing validated skills as code rather than relying on models to reason or retrieve information, ensuring deterministic and auditable results.

This paper introduces a coalescent-based framework to unify population structure and relatedness analysis, showing that full GRMs can replace PCs for modeling genetic covariance.

The Peruvian Genome Project collects and analyzes genomic data from native and mestizo populations in Peru to address underrepresentation in global genome databases and uncover genetic adaptations to local environments.

The paper analyzes genome-wide data from 432 Peruvian urban individuals to reveal fine-scale population structure, admixture dynamics, and demographic patterns shaped by ancient and recent events.

This study identifies altitude-associated immune gene expression differences in Peruvian Andean populations, revealing distinct transcriptomic profiles linked to high-altitude adaptation.

The paper uses metagenomics to analyze antibiotic resistance genes in sewage from hospitals and urban areas in a Peruvian city, finding high abundance of resistance genes in both samples.

This study presents a high-coverage whole-genome sequencing dataset of 1,171 admixed elderly Brazilians, identifying novel variants and demonstrating the utility of WGS for genomic and clinical research in underrepresented populations.

The paper examines genetic polymorphisms in NAT2, CYP2E1, and AADAC genes in Peruvian tuberculosis patients, finding high frequencies of slow metabolizer genotypes and implications for drug response and resistance.

The paper identifies a West African-associated regulatory variant with a strong female-specific effect on BMI and fat mass in Brazilian admixed populations.

This study analyzes gut microbiome composition of the Caral-Supe civilization using 16S rRNA and ITS sequencing from coprolite samples to identify microorganisms and potential diseases.

The paper analyzes African genetic contributions to the Americas, showing regional ancestry patterns and admixture dynamics linked to historical factors.

The paper investigates the association between genetic polymorphisms in IL-17, ICAM-1, and CD1 genes and susceptibility to Guillain-Barré Syndrome (GBS) in a mestizo population during a 2018 outbreak.

A common missense variant in FBN1 reduces height by 2.2 cm in Peruvians, showing strong positive selection and higher frequency in coastal Native American populations.

This study sequenced and analyzed genomes from Native American and mestizo populations in Peru to reconstruct their demographic history and genetic admixture patterns.