Galen E.B. Wright

The paper introduces a computational model to quantify tandem repeat instability using long-read sequencing data and applies it to identify unstable alleles in 256 HPRC cell lines.

The paper investigates the contribution of short tandem repeats (STRs) to age-related hearing loss phenotypes, finding they explain some missing heritability and identify risk associations.

The paper identifies genomic features distinguishing neuromuscular disorder genes from other genes using machine learning and statistical analysis.

This study identifies potential adverse effects of knocking down polyQ disorder genes using genomic data and highlights risks for drug targeting.

The paper identifies novel modifier genes for Huntington disease by combining population-scale gene expression data with patient genomic data.

This study characterizes ADME gene variation in sub-Saharan African populations, identifying novel variants and highlighting the need for tailored pharmacogenomic approaches.

This study identifies a genetic variant that reduces interruption between CAG and CCG repeats in the HTT gene, leading to earlier onset of Huntington disease and increased somatic instability.