Author

Cassandra L. McDonald

University of British ColumbiaORCID 0000-0001-5559-2494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alicia SemakaiD· 1 shared Ben VanderkrukiD· 1 shared Brad G. HoffmaniD· 1 shared Brett TrostiD· 1 shared Britt I. DrögemölleriD· 1 shared Charlotte M. Nguyen· 1 shared Chris KayiD· 1 shared Colin J. RossiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Alicia SemakaORCID

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2 papers

Recent·Most cited

Developmental BiologyDiabetesPeer-reviewedAug 10, 2021

H3K4 trimethylation is required for postnatal pancreatic endocrine cell functional maturation

Stephanie A. Campbell, Jocelyn Bégin, Cassandra L. McDonald…·Brad G. Hoffman

This study shows that H3K4 trimethylation is necessary for the functional maturation of pancreatic islet endocrine cells by activating genes involved in glucose-stimulated insulin secretion.

9 citations

mousebulk RNA-seq

𝕏 PostBluesky

GeneticsThe American Journal of Human GeneticsPeer-reviewedMay 16, 2019

Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease

Galen E.B. Wright, Jennifer A. Collins, Chris Kay…·Michael R. Hayden

This study identifies a genetic variant that reduces interruption between CAG and CCG repeats in the HTT gene, leading to earlier onset of Huntington disease and increased somatic instability.

201 citationstop 1%

humanDNA methylation

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