Increased 20-HETE signaling suppresses neurovascular coupling after ischemic stroke in regions beyond the infarct
Zhenzhou Li, Heather McConnell, Teresa L. Stackhouse, Martin M. Pike, Wenri H. Zhang, Anusha Mishra
This study identifies 20-HETE-dependent vasoconstriction as a mechanism impairing neurovascular coupling after stroke, showing that inhibiting its synthesis can restore blood flow in peri-infarct regions.
Frontiers in Cellular Neuroscience · Nov 8, 2021Peer-reviewedNeuroscience