The paper introduces a novel mouse model of mild subcortical stroke and shows that astrogliosis spreads widely and independently of microglia and age.

bioRxiv · Jul 18, 2025 · PreprintNeuroscience

Increased 20-HETE signaling suppresses neurovascular coupling after ischemic stroke in regions beyond the infarct

Zhenzhou Li, Heather McConnell, Teresa L. Stackhouse, Martin M. Pike, Wenri H. Zhang, Anusha Mishra

This study identifies 20-HETE-dependent vasoconstriction as a mechanism impairing neurovascular coupling after stroke, showing that inhibiting its synthesis can restore blood flow in peri-infarct regions.

Frontiers in Cellular Neuroscience · Nov 8, 2021Peer-reviewedNeuroscience

Spatially-mapped single-cell chromatin accessibility

Casey A. Thornton, Ryan M. Mulqueen, Kristof A. Torkenczy, Andrew Nishida, Eve G. Lowenstein, Andrew J. Fields, Frank J. Steemers, Wenri H. Zhang, Heather L. McConnell, Randy L Woltjer, Anusha Mishra, Kevin M. Wright, Andrew Adey

The paper introduces sciMAP-ATAC, a method for spatially resolved single-cell chromatin accessibility profiling, and applies it to study cortical lamination, spatial trajectories, and ischemic infarct progression in mouse and human tissues.

Nature Communications · Feb 24, 2021Peer-reviewedGenetics