Martin M. Pike

This study shows that stroke and Alzheimer's disease independently affect neurovascular function but together increase amyloid deposition in Tg2576 mice.

This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.

This study examines cerebral blood flow and reactivity in elastin haploinsufficient and 3xTg-AD mice, finding impaired cerebrovascular reactivity in combined genotypes.

This paper analyzes the thermodynamic and metabolic consequences of active trans-membrane water co-transport, showing it is not futile but integral to cellular homeostasis through synchronization with Na+,K+-ATPase.

This study identifies 20-HETE-dependent vasoconstriction as a mechanism impairing neurovascular coupling after stroke, showing that inhibiting its synthesis can restore blood flow in peri-infarct regions.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.